报告题目：Chemical Tools for Probing Glycosylation Dynamics In Vivo

　　报 告 人：陈兴 北京大学教授　　 　　 

　　邀 请 人：天津工业生物所 水雯箐研究员　　 

　　报告时间：4月23日 14:00-15:30　　 

　　报告地点：天津工业生物所 C408报告厅　　 

　　报告摘要：

　　Glycosylation plays a key role in mediating molecular recognition, development, and cell signaling. Intriguingly, cellular glycans are highly dynamic in various physiological and pathological processes. Our research group works on developing chemical tools to label, visualize, and modulate glycosylation in living systems. Here, we present the development of a liposome-based strategy for cell-selective metabolic labeling of glycans and a FRET-based method for protein-specific imaging of cell-surface glycans. Furthermore, we have applied those chemical tools to dissect the glycosylation changes during cardiac hypertrophy and tumor progression. Finally, we are interested in developing new imaging modalities other than the more conventional fluorescence microscopy for glycan visualization. A recently developed bioorthogoal Raman imaging technique will be discussed.　　

　　报告人简介：

　　陈兴教授从事糖生物学和化学生物学领域的交叉前沿研究。他在清华大学获得学士学位，而后在美国加州大学伯克利分校化学系分析获得博士学位，进而在哈佛大学医学院完成结构生物学和免疫学方面的博士后研究。2010年起在北京大学化学和化工学院担任研究员，先后获得国家杰出青年基金、中国化学会青年科学家奖，杜邦青年学者奖，药明康德生命和化学领域优秀人才奖等荣誉和奖项。