Kuiling Ding

Character introduction

Kuiling Ding received his B.S. in chemistry from Zhengzhou University in 1985 before studying physical organic chemistry at Nanjing University, where he received a Ph.D. in 1990 with Professor Yangjie Wu. He became an assistant professor at Zhengzhou University in 1990 and a full professor at the same university in 1995. During 1993-1994, he was engaged in a postdoctoral research with Professor Teruo Matsuura at Ryukoku University in Japan. In the period from 1997 to 1998, he was a UNESCO research fellow with Professor Koichi Mikami at Tokyo Institute of Technology in Japan. He joined Shanghai Institute of Organic Chemistry, CAS, in Dec of 1998 as a professor of chemistry and had been the director of the institute in the period of 2009-2019. He moved to Shanghai Jiaotong University as an executive vice president in 2018. His research interests include the development of new methodologies and novel catalysts for green & sustainable chemistry including asymmetric catalysis and CO2 transformation. He received National Natural Science Award of China in 2009, the 1st Yoshida Prize of International Organic Chemistry Foundation (IOCF) Japan in 2015, and Humboldt Research Award in 2016. He was elected a member of Chinese Academy of Sciences in 2013.

Topic: A Story of SKP/Pd Catalyst: Mechanistic Understanding, Process Innovation & Drug Discovery

Abstract  The concept of "cooperative catalysis" has been recognized as one of the most powerful approaches for stimulating innovations of the processes in pharmaceutical, material and chemical industries. In this talk, a case study on the cooperative catalysis of SKP/Pd in asymmetric allylic coupling reactions of MBH adducts will be presented by focusing mechanistic understanding, process innovation and discovery of anti-cancer molecules.1


KEY WORDS: palladium, allylic coupling, SKP ligand
REFERENCES
1.a) Z. Han, Z. Wang, X. Zhang, K. Ding, Angew Chem. Int. Ed. 2009, 48, 5345; b) X. Wang, Z. Han, Z. Wang, K. Ding, Angew. Chem. Int. Ed. 2012, 51, 936. c) X. Wang, F. Meng, Y. Wang, Z. Han, Y. Chen, L. Liu, Z. Wang, K. Ding, Angew Chem. Int. Ed. 2012, 51, 9276. d) Z.-Y. Cao, X. Wang, C. Tan, X.-L. Zhao, J. Zhou, K. Ding, J. Am. Chem. Soc. 2013, 135, 8197. e) X. Wang, P. Guo, X.B. Wang, F. Meng, Z. Wang, K. Ding, J. Am. Chem. Soc. 2014, 136, 405. f) Liu, J.; Han, Z.; Wang, X.; Wang, Z.; Ding, K. J. Am. Chem. Soc. 2015, 137, 15346–15349. g) X. Wang, X. Wang, Z. Han, Z. Wang, K. Ding, Angew. Chem. Int. Ed. 2017, 56, 1116. h) J. Liu, Z. Han, X. Wang, F. Meng, Z. Wang, K. Ding, Angew. Chem. Int. Ed. 2017, 56, 5050. i) H. Wang, L. Yu, M. Xie, J. Wu, G. Qu, K Ding, H. Guo, Chem. Eur. J. 2018, 24, 1425-1430. j) P. Zhou, Y. Liu, L. Zhou, K. Zhu, K. Feng, H. Zhang, Y. Liang, H. Jiang, C. Luo, M. Liu, Y. Wang, J. Med. Chem. 2016, 59, 10329. k) P. Zhou, Y. Liang, H. Zhang, H. Jiang, K. Feng, P. Xu, J. Wang, X. Wang, K. Ding, C. Luo, M. Liu, Y. Wang, Eur. J. Med. Chem. 2018, 144, 817-842. h) Y. Ge, Z. Han, Z. Wang, C.-G. Feng, Q. Zhao, G.-Q. Lin, K. Ding, Angew. Chem. Int. Ed. 2018, 57, 13140. i) Y. Ge, Z. Han, Z. Wang, K. Ding, J. Am. Chem. Soc. 2019, 141, 8981. J) P. Guo, R. Zhang, X. Wang, Z. Wang, K. Ding, Chem. Eur. J. 2019, 25, in the press.

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